A guided missile attack on a car in the Mazzeh neighborhood of Damascus has left at least two civilians dead, according to Syrian state media.
The Mazzeh area is known for housing embassies and security headquarters.
Three people were also wounded in the explosion that happened near the Syrian Information Ministry.
Witnesses reported damage to a nearby hotel and several vehicles that were set ablaze in the aftermath of the blast.
Ambulances rushed to the site of the explosion where people gathered around the mangled four-wheel drive, AFP reported.
Some Israeli news reports suggested that Islamic Jihad's Secretary-General, Ziad al-Nakhala, was the target of the missile attack.
The Palestinian resistance movement, however, issued a statement rejecting reports that Nakhala’s vehicle was hit as "completely false."
The Israeli regime has repeatedly struck Syria with air raids and artillery attacks since last October, when the ongoing genocidal war in Gaza began.
Earlier this month, the Syrian government said seven civilians were killed in an Israeli airstrike on a residential and commercial building in Mazzeh.
Syria’s government said at the time the Israeli military launched three missiles from the direction of the occupied Golan Heights at a building in Mezzeh.
The Israeli regime rarely comments on individual strikes in Syria.